Back to Search
Start Over
Risk factors for frontal fibrosing alopecia: A case-control study in a multiracial population.
- Source :
-
Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2021 Mar; Vol. 84 (3), pp. 712-718. Date of Electronic Publication: 2020 Aug 22. - Publication Year :
- 2021
-
Abstract
- Background: Frontal fibrosing alopecia (FFA) is a chronic cicatricial alopecia with unknown etiology and a worldwide rising incidence.<br />Objective: The objective of this study was to evaluate the association of FFA with demographic and exposure factors in a Brazilian multiracial population.<br />Methods: A multicenter case-control study was conducted in 11 referral centers throughout Brazil. The study was a case-control study that prospectively recruited 902 participants (451 patients with FFA and 451 sex-matched control individuals). Study participants completed a thorough questionnaire comprising variables grouped as baseline demographics, environmental exposure, diet, hormonal factors, allergies, and hair and skin care.<br />Results: When adjusted by sex, age, menopause, and skin color, FFA was associated with hair straightening with formalin (odds ratio [OR], 3.18), use of ordinary (nondermatologic) facial soap (OR, 2.09) and facial moisturizer (OR, 1.99), thyroid disorders (OR, 1.69), and rosacea (OR, 2.08). Smokers (OR, 0.33) and users of antiresidue/clarifying shampoo (OR, 0.35) presented a negative association with FFA. There was no association with the use of sunscreen.<br />Limitations: Recall bias.<br />Conclusions: The association with moisturizers, ordinary facial soap, and hair straightening with formalin and the negative association with antiresidue/clarifying shampoo reinforce the possibility of an exogenous particle triggering FFA.<br /> (Copyright © 2020 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Alopecia etiology
Alopecia pathology
Brazil epidemiology
Case-Control Studies
Cicatrix etiology
Cicatrix pathology
Female
Forehead
Formaldehyde adverse effects
Hair Preparations adverse effects
Hair Preparations chemistry
Humans
Incidence
Male
Middle Aged
Prospective Studies
Protective Factors
Risk Assessment statistics & numerical data
Risk Factors
Skin pathology
Soaps adverse effects
Surveys and Questionnaires statistics & numerical data
Alopecia epidemiology
Cicatrix epidemiology
Rosacea epidemiology
Smoking epidemiology
Thyroid Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6787
- Volume :
- 84
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of the American Academy of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 32835739
- Full Text :
- https://doi.org/10.1016/j.jaad.2020.08.076