Back to Search
Start Over
High- density lipoprotein function is abnormal in idiopathic inflammatory myopathies.
- Source :
-
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2020 Nov 01; Vol. 59 (11), pp. 3515-3525. - Publication Year :
- 2020
-
Abstract
- Objective: Damage to the vascular endothelium is strongly implicated in the pathogenesis of idiopathic inflammatory myopathies (IIM). Normally, high-density lipoprotein (HDL) protects the vascular endothelium from damage from oxidized phospholipids, which accumulate under conditions of oxidative stress. The current work evaluated the antioxidant function of HDL in IIM patients.<br />Methods: HDL's antioxidant function was measured in IIM patients using a cell-free assay, which assesses the ability of isolated patient HDL to inhibit oxidation of low-density lipoproteins and is reported as the HDL inflammatory index (HII). Cholesterol profiles were measured for all patients, and subgroup analysis included assessment of oxidized fatty acids in HDL and plasma MPO activity. A subgroup of IIM patients was compared with healthy controls.<br />Results: The antioxidant function of HDL was significantly worse in patients with IIM (n = 95) compared with healthy controls (n = 41) [mean (S.d.) HII 1.12 (0.61) vs 0.82 (0.13), P < 0.0001]. Higher HII associated with higher plasma MPO activity [mean (S.d.) 13.2 (9.1) vs 9.1 (4.6), P = 0.0006] and higher oxidized fatty acids in HDL. Higher 5-hydroxyeicosatetraenoic acid in HDL correlated with worse diffusion capacity in patients with interstitial lung disease (r = -0.58, P = 0.02), and HDL's antioxidant function was most impaired in patients with autoantibodies against melanoma differentiation-associated protein 5 (MDA5) or anti-synthetase antibodies. In multivariate analysis including 182 IIM patients, higher HII was associated with higher disease activity and DM diagnosis.<br />Conclusion: The antioxidant function of HDL is abnormal in IIM patients and may warrant further investigation for its role in propagating microvascular inflammation and damage in this patient population.<br /> (© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Adult
Aged
Amino Acyl-tRNA Synthetases immunology
Autoantibodies immunology
Case-Control Studies
Chromatography, Liquid
Dermatomyositis drug therapy
Dermatomyositis immunology
Dermatomyositis metabolism
Endothelium, Vascular
Fatty Acids metabolism
Female
Glucocorticoids therapeutic use
Humans
Hydroxyeicosatetraenoic Acids metabolism
Immunologic Factors therapeutic use
Immunosuppressive Agents therapeutic use
Interferon-Induced Helicase, IFIH1 immunology
Lung Diseases, Interstitial immunology
Male
Middle Aged
Myositis drug therapy
Myositis immunology
Myositis, Inclusion Body drug therapy
Myositis, Inclusion Body immunology
Myositis, Inclusion Body metabolism
Oxidation-Reduction
Peroxidase metabolism
Polymyositis drug therapy
Polymyositis immunology
Polymyositis metabolism
Pulmonary Diffusing Capacity
Spectrometry, Mass, Electrospray Ionization
Lipoproteins, HDL metabolism
Lipoproteins, LDL metabolism
Lung Diseases, Interstitial metabolism
Myositis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1462-0332
- Volume :
- 59
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Rheumatology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 32830270
- Full Text :
- https://doi.org/10.1093/rheumatology/keaa273