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Red Blood Cell Distribution Width (RDW) Predicts COVID-19 Severity: A Prospective, Observational Study from the Cincinnati SARS-CoV-2 Emergency Department Cohort.

Authors :
Henry BM
Benoit JL
Benoit S
Pulvino C
Berger BA
Olivera MHS
Crutchfield CA
Lippi G
Source :
Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2020 Aug 21; Vol. 10 (9). Date of Electronic Publication: 2020 Aug 21.
Publication Year :
2020

Abstract

Since previous evidence has demonstrated that red blood cell distribution width (RDW) may be a useful prognostic parameter in many critical illnesses and infectious diseases, we investigated the utility of RDW for monitoring patients with coronavirus disease 2019 (COVID-19). The study population consisted of 49 COVID-19 patients, including 16 (32.6%) with severe illness, 12 (24.5%) with severe acute kidney injury (AKI), and 8 (16.3%) requiring renal replacement therapy (RRT). The predictive value of blood tests, performed during emergency department evaluation, was then addressed. A progressive increase of RDW was observed with advancing COVID-19 severity. The area under the curve (AUC) of RDW was 0.73 for predicting severe illness, 0.80 for severe AKI, and 0.83 for RRT, respectively. In multivariate analysis, elevated RDW was associated with 9-fold and 16-fold increased odds of severe COVID-19 and AKI, respectively. The results of this study suggest that RDW should be part of routine laboratory assessment and monitoring of COVID-19.

Details

Language :
English
ISSN :
2075-4418
Volume :
10
Issue :
9
Database :
MEDLINE
Journal :
Diagnostics (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
32825629
Full Text :
https://doi.org/10.3390/diagnostics10090618