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MS Analysis of DNA Modifications in Urinary/Body Fluids.
- Source :
-
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2198, pp. 109-122. - Publication Year :
- 2021
-
Abstract
- Analytical techniques based on mass spectrometry allow to analyze DNA modifications in body fluids. Here we describe two chromatographic methods that can be used for the simultaneous determination of the modified DNA bases and nucleosides in the same urine sample: isotope-dilution automated online two-dimensional ultraperformance liquid chromatography with tandem mass spectrometry (2D-UPLC-MS/MS) and high-performance liquid chromatography coupled with gas chromatography and mass spectrometry (HPLC/GC/MS).
Details
- Language :
- English
- ISSN :
- 1940-6029
- Volume :
- 2198
- Database :
- MEDLINE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 32822026
- Full Text :
- https://doi.org/10.1007/978-1-0716-0876-0_9