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Preparing Map of Chromosome Territory Distribution Frequency.
- Source :
-
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2157, pp. 213-219. - Publication Year :
- 2021
-
Abstract
- The chromosomes in mammalian interphase nuclei are organized into domains called chromosome territories that play a major role in nuclear organization. Here we propose a methodology that combines the use of micro-patterning of adhesive molecules to impose single-cell geometry, with visualization of chromosome territories. This allows obtaining a representative statistical map of the absolute positions of chromosome territories relative to the geometry imposed to the cell population by combining the signal from each cell.
Details
- Language :
- English
- ISSN :
- 1940-6029
- Volume :
- 2157
- Database :
- MEDLINE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 32820406
- Full Text :
- https://doi.org/10.1007/978-1-0716-0664-3_12