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Infertile Men Have Higher Prostate-specific Antigen Values than Fertile Individuals of Comparable Age.
- Source :
-
European urology [Eur Urol] 2021 Feb; Vol. 79 (2), pp. 234-240. Date of Electronic Publication: 2020 Aug 17. - Publication Year :
- 2021
-
Abstract
- Background: Infertile men are at greater risk for oncological and nononcological chronic disease than fertile individuals.<br />Objective: To investigate prostate-specific antigen (PSA) values in men presenting for primary couple's infertility compared with a cohort of fertile individuals, according to the recommendation of the European Association of Urology guidelines that a first PSA assessment should be done at 40-45 yr of age.<br />Design, Setting, and Participants: This is a cross-sectional study. Data from 956 (90%) infertile men and 102 (9.6%) fertile participants were analysed. Circulating hormones, total PSA, and semen parameters were investigated in every man.<br />Outcome Measurements and Statistical Analysis: Descriptive statistics, local polynomial smoothing, and linear regression models were used to test potential associations with PSA levels.<br />Results and Limitations: Overall, PSA >1 ng/ml was found in 318 (30%) men. Serum PSA was higher (p = 0.02), while serum testosterone (p < 0.01) was lower in infertile than in fertile men. In participants younger than 40 yr, 176 (27%) men had PSA >1 ng/ml; of them, a greater proportion were infertile (28% infertile vs 17% fertile, p = 0.03). At multivariable linear regression analysis, infertile status (coefficient 0.21; 95% confidence interval 0.02-0.39) was associated with higher PSA values, after adjusting for age and serum testosterone level. This was a single-centre study, raising the possibility of selection biases.<br />Conclusions: Infertile men have higher PSA values than fertile individuals. Of all, almost one out of three primary infertile men younger than 40 yr has a first total PSA value of >1 ng/ml.<br />Patient Summary: In this study, we observed that (1) infertile men have higher prostate-specific antigen (PSA) values than fertile individuals and (2) a greater proportion of infertile men younger than 40 yr had total PSA >1 ng/ml at the first assessment. These data might be relevant to study the potential clinical impact of more rigorous screening in primary infertile men.<br /> (Copyright © 2020 European Association of Urology. Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-7560
- Volume :
- 79
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European urology
- Publication Type :
- Academic Journal
- Accession number :
- 32814638
- Full Text :
- https://doi.org/10.1016/j.eururo.2020.08.001