Back to Search
Start Over
Galectin-1 is inversely associated with type 2 diabetes independently of obesity - A SCAPIS pilot study.
- Source :
-
Metabolism open [Metabol Open] 2019 Sep 05; Vol. 4, pp. 100017. Date of Electronic Publication: 2019 Sep 05 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Objectives: Galectin-1 is a recently discovered adipokine that increases with obesity and increased energy intake in adipose tissue. Our aim was to assess whether serum galectin-1 is associated with type 2 diabetes (T2D) and other parameters of the metabolic syndrome independently of body mass index (BMI) in a cohort from the general population.<br />Methods: In this cross-sectional population-based cohort study from the western part of Sweden, we investigated associations between serum galectin-1, clinical characteristics and inflammatory markers in 989 women and men aged 50-65 years [part of the Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot cohort].<br />Results: We showed in linear models that serum galectin-1 was independently and: (1) inversely associated with T2D (p < 0.05) and glucose (p < 0.05); and (2) positively associated with age (p < 0.01), sex (p < 0.01), BMI (p < 0.01), insulin (p < 0.01) and C-reactive protein (p < 0.01). Furthermore, galectin-1 demonstrated univariate correlations with triglycerides (r = 0.20, p < 0.01), homeostasis model assessment for insulin resistance (r = 0.24, p < 0.01), tumor necrosis factor-α (r = 0.24, p < 0.01), interleukin-6 (IL-6; r = 0.20, p < 0.01) and HbA1c (r = 0.14, p < 0.01).<br />Conclusion: In a cross-sectional study of a middle-aged population, we showed that serum galectin-1 is: (1) inversely associated with T2D independently of BMI; and (2) independently associated with other markers of the metabolic syndrome These results warrant prospective and functional studies on the role of galectin-1 in T2D.<br /> (© 2019 The Authors.)
Details
- Language :
- English
- ISSN :
- 2589-9368
- Volume :
- 4
- Database :
- MEDLINE
- Journal :
- Metabolism open
- Publication Type :
- Academic Journal
- Accession number :
- 32812946
- Full Text :
- https://doi.org/10.1016/j.metop.2019.100017