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Cefoxitin: its role in treatment and prophylaxis of obstetric and gynecologic infections.
- Source :
-
Reviews of infectious diseases [Rev Infect Dis] 1988 Jan-Feb; Vol. 10 (1), pp. 76-91. - Publication Year :
- 1988
-
Abstract
- Cefoxitin has become one of the most used parenteral antibiotics in the United States, perhaps because of a broad spectrum of activity, including activity against Bacteroides fragilis, which makes the drug suitable for prevention and treatment of intraabdominal and pelvic infections. This review focuses on the use of cefoxitin in obstetric and gynecologic infections, with comparisons to older and newer antibiotics. Numerous studies have shown that cefoxitin is clearly effective; in most of these studies, however, either the initial infection rates were low or the sample sizes were small--circumstances making it difficult to establish the superiority of any one agent. Thus, the necessity of using a drug with activity against B. fragilis for prevention and treatment of pelvic infections has not been proven. Several antibiotics without such activity have been equally effective. Cefoxitin may be of particular value when combined with surgical drainage of pelvic abscesses, infections in which control of B. fragilis may be especially important to outcome.
- Subjects :
- Bacterial Infections prevention & control
Cefoxitin pharmacokinetics
Cefoxitin pharmacology
Cesarean Section
Female
Genital Diseases, Female prevention & control
Gonorrhea drug therapy
Humans
Hysterectomy
Pelvic Inflammatory Disease drug therapy
Pregnancy
Pregnancy Complications, Infectious prevention & control
Premedication
Bacterial Infections drug therapy
Cefoxitin therapeutic use
Genital Diseases, Female drug therapy
Pregnancy Complications, Infectious drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0162-0886
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Reviews of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 3281224
- Full Text :
- https://doi.org/10.1093/clinids/10.1.76