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Tubular injury and cell-cycle arrest biomarkers to predict acute kidney injury in noncritically ill children receiving aminoglycosides.
- Source :
-
Biomarkers in medicine [Biomark Med] 2020 Jul; Vol. 14 (10), pp. 879-894. Date of Electronic Publication: 2020 Aug 18. - Publication Year :
- 2020
-
Abstract
- Aim: NGAL, IL-18, KIM-1 as well as urinary TIMP2 and IGFBP7 and their mathematical product (TIMP2*IGFBP7) were evaluated for detecting pediatric aminoglycoside acute kidney injury (AG-AKI). Methods: In a prospective study, noncritically ill children received aminoglycosides (AG) ≥3 days. The area under the curve (AUC) for biomarkers to detect AKI was calculated by a) days before AKI onset; b) treatment days. Results: There were 113 AG episodes (68% febrile neutropenia). The AKI group had a higher proportion with febrile neutropenia. The AKI group had significantly lower NGAL 3 days before AKI, as patients with febrile neutropenia had a lower NGAL during AG treatment (p < 0.05). NGAL, IL-18 and TIMP2*IGFBP7 had AUC ≥0.73 at 3, 2 and 2 days before AKI onset. Conclusion: NGAL, IL-18 and TIMP2*IGFBP7 were modest early biomarkers of AG-AKI. Febrile neutropenia was associated with lower NGAL.
- Subjects :
- Humans
Male
Female
Child
Child, Preschool
Interleukin-18 urine
Infant
Prospective Studies
Cell Cycle Checkpoints drug effects
Hepatitis A Virus Cellular Receptor 1 metabolism
Hepatitis A Virus Cellular Receptor 1 analysis
Adolescent
Kidney Tubules pathology
Kidney Tubules metabolism
Kidney Tubules drug effects
Febrile Neutropenia chemically induced
Acute Kidney Injury chemically induced
Acute Kidney Injury urine
Acute Kidney Injury diagnosis
Biomarkers urine
Biomarkers metabolism
Insulin-Like Growth Factor Binding Proteins urine
Tissue Inhibitor of Metalloproteinase-2 urine
Lipocalin-2 urine
Aminoglycosides adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1752-0371
- Volume :
- 14
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Biomarkers in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32808826
- Full Text :
- https://doi.org/10.2217/bmm-2019-0419