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Imaging characteristics and prognostic values of hepatic epithelioid hemangioendothelioma on 18 F-FDG PET/CT.
- Source :
-
Clinical and experimental medicine [Clin Exp Med] 2020 Nov; Vol. 20 (4), pp. 557-567. Date of Electronic Publication: 2020 Aug 14. - Publication Year :
- 2020
-
Abstract
- Hepatic epithelioid hemangioendothelioma (HEHE) is a low-to-intermediate-grade malignant mesenchymal tumor. The diagnostic and prognostic values of 2-[18F] fluoro-2-deoxy-D-glucose ( <superscript>18</superscript> F-FDG) positron emission tomography/computed tomography (PET/CT) to patients with HEHE have not been fully validated. Patient survival outcomes (including overall survival [OS] and progression-free survival [PFS]), lesions characteristics and semi-quantitative parameters, in terms of maximum standardized uptake value (SUV <subscript>max</subscript> ), peak SUV (SUV <subscript>peak</subscript> ), total lesion glycolysis (TLG) and metabolic tumor volume (MTV) on <superscript>18</superscript> F-FDG PET/CT of 20 cases with HEHE were measured and analyzed. A total of 310 liver lesions were detected (excluding the diffuse-type lesions in 3 cases). Most lesions had higher SUV <subscript>max</subscript> in delayed imaging than in early imaging (P = 0.013). Patients with multiple organs involved had higher death rate (P = 0.022), higher progression rate (P = 0.020), shorter OS (P = 0.011), larger lesion SUV <subscript>max</subscript> (P = 0.048) and TLG (P = 0.033) than those with only liver involved. The area under curves (AUCs) from the receiver operating characteristic (ROC) curve analysis were 0.960, 0.949, 0.980 and 0.960 for SUV <subscript>max,</subscript> SUV <subscript>peak</subscript> , TLG and MTV, respectively, in predicting OS (P = 0.005, 0.008, 0.001 and 0.024, respectively). For predicting PFS, the AUCs were 0.791, 0.824, 0.857 and 0.813 (P = 0.036, 0.019, 0.010 and 0.024), respectively. Dual-time-point imaging may improve lesions detectability. Patients with multiple organ involved had worse prognosis. The higher SUV <subscript>max</subscript> , SUV <subscript>peak</subscript> , TLG and MTV of lesions, the worse prognosis of patients were found.
- Subjects :
- Adult
Aged
Female
Fluorodeoxyglucose F18 pharmacokinetics
Follow-Up Studies
Hemangioendothelioma, Epithelioid pathology
Hemangioendothelioma, Epithelioid therapy
Humans
Liver Neoplasms pathology
Liver Neoplasms therapy
Male
Middle Aged
Prognosis
ROC Curve
Radiopharmaceuticals pharmacokinetics
Tumor Burden
Hemangioendothelioma, Epithelioid diagnostic imaging
Hemangioendothelioma, Epithelioid mortality
Liver Neoplasms diagnostic imaging
Liver Neoplasms mortality
Positron Emission Tomography Computed Tomography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1591-9528
- Volume :
- 20
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical and experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32797371
- Full Text :
- https://doi.org/10.1007/s10238-020-00653-0