Back to Search
Start Over
Role of B cells in immune-mediated dermatoses.
- Source :
-
Molecular immunology [Mol Immunol] 2020 Oct; Vol. 126, pp. 95-100. Date of Electronic Publication: 2020 Aug 11. - Publication Year :
- 2020
-
Abstract
- Although T cells are considered as the central component in immune-mediated diseases, supportive evidence has demonstrated that B cells also contribute to the progression of these diseases. B cells are divided into various subsets according to their secreted cytokines. Different B cell subsets play diverse roles in immune-mediated dermatoses. Regulatory B cells (Bregs) are defined functionally by their ability to secrete IL-10, which has been revealed to contribute to immunological tolerance. Drugs that deplete B cells, such as rituximab, are now used for the treatment of several immune-mediated dermatoses. In this review, we present and discuss the current knowledge on the roles of B cells in several immune-mediate dermatoses including psoriasis, pemphigus, bullous pemphigoid, and dermatomyositis, atopic dermatitis.<br /> (Copyright © 2020. Published by Elsevier Ltd.)
- Subjects :
- Animals
B-Lymphocytes, Regulatory drug effects
B-Lymphocytes, Regulatory metabolism
Dermatitis, Atopic blood
Dermatitis, Atopic drug therapy
Dermatitis, Atopic pathology
Dermatomyositis blood
Dermatomyositis drug therapy
Dermatomyositis pathology
Desmoglein 3 metabolism
Disease Models, Animal
Humans
Immunologic Factors pharmacology
Immunologic Factors therapeutic use
Interleukin-10 metabolism
Lymphocyte Depletion methods
Pemphigoid, Bullous blood
Pemphigoid, Bullous drug therapy
Pemphigoid, Bullous pathology
Pemphigus blood
Pemphigus drug therapy
Pemphigus pathology
Psoriasis blood
Psoriasis drug therapy
Psoriasis pathology
Skin immunology
Skin pathology
B-Lymphocytes, Regulatory immunology
Dermatitis, Atopic immunology
Dermatomyositis immunology
Pemphigoid, Bullous immunology
Pemphigus immunology
Psoriasis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9142
- Volume :
- 126
- Database :
- MEDLINE
- Journal :
- Molecular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 32795664
- Full Text :
- https://doi.org/10.1016/j.molimm.2020.07.016