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Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats.
- Source :
-
BMC endocrine disorders [BMC Endocr Disord] 2020 Aug 14; Vol. 20 (1), pp. 124. Date of Electronic Publication: 2020 Aug 14. - Publication Year :
- 2020
-
Abstract
- Background: Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle (LV) in obese rats.<br />Methods: Sprague Dawley rats (250 ± 5 g) were obtained and divided into two groups: the control (C) group was fed with a standard diet, and the obese (Ob) group was fed hyper caloric diet with a high fructose-fat content for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities.<br />Results: The body weight in the Ob group was increased compared to that in the control group, (p < 0.001); in addition, increased glucose, cholesterol and triglyceride concentrations (p < 0.05) as well as increased levels of the adhesion molecules ICAM-1 and, VCAM-1 (p < 0.01) were found in the Ob group vs the C group. On ultrasound, 75% of the Ob group presented fatty liver and distal joint abnormalities.<br />Conclusion: Obese rats exhibit endothelial dysfunction and musculoskeletal changes, also, fatty liver and articular cysts in the posterior region of the distal lower- extremity joints.
- Subjects :
- Anatomy, Cross-Sectional
Animals
Endothelium, Vascular pathology
Endothelium, Vascular physiopathology
Heart physiopathology
Intercellular Adhesion Molecule-1 metabolism
Liver physiopathology
Male
Musculoskeletal Diseases diagnosis
Musculoskeletal Diseases etiology
Musculoskeletal Diseases pathology
Musculoskeletal Diseases physiopathology
Musculoskeletal System pathology
Musculoskeletal System physiopathology
Myocardium pathology
Obesity complications
Obesity physiopathology
Rats
Rats, Sprague-Dawley
Ultrasonography
Vascular Diseases diagnosis
Vascular Diseases etiology
Vascular Diseases pathology
Vascular Diseases physiopathology
Ventricular Dysfunction, Left diagnosis
Ventricular Dysfunction, Left etiology
Ventricular Dysfunction, Left pathology
Ventricular Dysfunction, Left physiopathology
Endothelium, Vascular diagnostic imaging
Heart diagnostic imaging
Liver diagnostic imaging
Musculoskeletal System diagnostic imaging
Obesity diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1472-6823
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC endocrine disorders
- Publication Type :
- Academic Journal
- Accession number :
- 32795274
- Full Text :
- https://doi.org/10.1186/s12902-020-00603-7