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Chronic stress induced depressive-like behaviors in a classical murine model of Parkinson's disease.
- Source :
-
Behavioural brain research [Behav Brain Res] 2021 Feb 05; Vol. 399, pp. 112816. Date of Electronic Publication: 2020 Aug 09. - Publication Year :
- 2021
-
Abstract
- Depression occurs in around 40 % of patients with Parkinson's disease (PD) and contributes to severe disability and a poor quality of life. The underlying mechanisms and pathophysiology of depression in PD (PDD) remain obscure, due to a lack of stable animal models of PDD. In this study, we established a PDD model by inducing exposure to chronic mild (CMS) and strong stress (CSS) using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in PD mice. We detected changes in motor and non-motor symptoms, brain structure, neurotransmitters, levels of 5-HT related genes and inflammation. CMS exposed PD (PDMS) mice exhibited obviously decreased levels of neuromuscular strength and enhanced levels of inflammation, compared with that of control mice. CSS exposed MPTP (PDSS) mice exhibited the highest level of motor impairment and depression states along with the highest levels of inflammation enhancement and a decrease in the expression levels of 5-hydroxytryptamine (5-HT) related genes in all groups. Our results suggested that CSS can successfully induce stable depression like symptoms in sub-chronic MPTP PD mice and appears to be a valuable tool for investigating PDD. Furthermore, it was found that 5-HT system dysfunction may contribute to depression like symptoms in PD.<br /> (Copyright © 2020. Published by Elsevier B.V.)
- Subjects :
- Animals
Depression immunology
Depression metabolism
Depression physiopathology
Disease Models, Animal
Inflammation immunology
Inflammation metabolism
Male
Mice
Mice, Inbred C57BL
Serotonin genetics
Stress, Psychological immunology
Stress, Psychological metabolism
Stress, Psychological physiopathology
Behavior, Animal physiology
Depression etiology
Inflammation etiology
MPTP Poisoning immunology
MPTP Poisoning metabolism
MPTP Poisoning physiopathology
Parkinson Disease immunology
Parkinson Disease metabolism
Parkinson Disease physiopathology
Serotonin metabolism
Stress, Psychological complications
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 399
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 32783904
- Full Text :
- https://doi.org/10.1016/j.bbr.2020.112816