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Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression.
- Source :
-
Physiology (Bethesda, Md.) [Physiology (Bethesda)] 2020 Sep 01; Vol. 35 (5), pp. 288-301. - Publication Year :
- 2020
-
Abstract
- The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. This review highlights key mechanisms that have been proposed to contribute to COVID-19 progression from viral entry to multisystem organ failure, as well as the central role of the immune response in successful viral clearance or progression to death.
Details
- Language :
- English
- ISSN :
- 1548-9221
- Volume :
- 35
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Physiology (Bethesda, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 32783610
- Full Text :
- https://doi.org/10.1152/physiol.00019.2020