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Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients.
- Source :
-
BMC cardiovascular disorders [BMC Cardiovasc Disord] 2020 Aug 10; Vol. 20 (1), pp. 365. Date of Electronic Publication: 2020 Aug 10. - Publication Year :
- 2020
-
Abstract
- Background: Acute aortic dissection (AAD) is an acute life-threatening cardiovascular disease, which is frequently complicated with oxygenation impairment (OI). We aim to investigate predictors of the development of OI in the patients with AAD.<br />Methods: We retrospectively collected clinical data of AAD in hypertensive patients from July 2012 to March 2020. The patients included in this study were divided into OI (+) group (oxygenation index≤200) and OI (-) group (oxygenation index> 200). Both groups were compared according to demographic and clinical characteristics, and laboratory findings. Characteristics of hypertension in the patients with AAD were described. Predictors for the development of OI were assessed. And cutoff values were determined by receiver operating characteristics (ROC) curve.<br />Results: A total of 208 patients were included in this study and the incidence of OI was 32.2%. In OI (+) group, patients had significantly higher peak body temperature (37.85 ± 0.60 vs 37.64 ± 0.44 °C, P = .005), higher levels of CRP (42.70 ± 28.27 vs 13.90 ± 18.70 mg/L, P = .000) and procalcitonin (1.07 ± 3.92 vs 0.31 ± 0.77μg/L, P = .027), and lower levels of albumin (34.21 ± 5.65 vs 37.73 ± 4.70 g/L, P = .000). Spearman's rank correlation test showed that the minimum oxygenation index was positively correlated with albumin, and was negatively correlated with the peak body temperature, serum CRP, procalcitonin, BNP and troponin. The stepwise multiple linear regression analysis showed that the peak body temperature, serum CRP and albumin were independently associated with development of OI. An optimal cutoff value for CRP for predicting OI was ≥9.20 mg/L, with a sensitivity of 91.0% and a specificity of 61.0%.<br />Conclusions: The peak body temperature, serum CRP and albumin were independent predictors of OI development in the patients with AAD. The serum CRP on admission≥9.20 mg/L might be a valuable and reliable indicator in predicting the development of OI.
- Subjects :
- Acute Disease
Adult
Aged
Aged, 80 and over
Aortic Dissection blood
Aortic Dissection diagnosis
Aortic Dissection surgery
Aortic Aneurysm blood
Aortic Aneurysm diagnosis
Aortic Aneurysm surgery
Biomarkers blood
Body Temperature
C-Reactive Protein analysis
Female
Humans
Hypertension blood
Hypertension diagnosis
Lung Diseases blood
Lung Diseases diagnosis
Male
Middle Aged
Retrospective Studies
Risk Assessment
Risk Factors
Serum Albumin, Human analysis
Aortic Dissection complications
Aortic Aneurysm complications
Hypertension complications
Lung Diseases etiology
Oxygen blood
Oxygen Consumption
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2261
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cardiovascular disorders
- Publication Type :
- Academic Journal
- Accession number :
- 32778051
- Full Text :
- https://doi.org/10.1186/s12872-020-01652-5