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Metastatic head and neck cutaneous basal cell carcinomas: a retrospective observational study.
- Source :
-
Archives of dermatological research [Arch Dermatol Res] 2021 Aug; Vol. 313 (6), pp. 439-443. Date of Electronic Publication: 2020 Aug 10. - Publication Year :
- 2021
-
Abstract
- Cutaneous basal cell carcinoma is usually an indolent and slow-growing tumor with potential for local invasion and recurrence; however, metastatic events are exceedingly rare. The annual incidence of metastasis is estimated to range between 0.00281 and 0.05%. A retrospective search in the pathology database of a single tertiary institution was performed in the period between 1999 to 2019. Primary cutaneous metastatic basal cell carcinomas had paraffin blocks and glass slides retrieved. A total of 8673 cases was identified. The overall prevalence of metastatic tumors was 0.05% (4/8673). The median patient's age at diagnosis was 61 years old (range 52-79). The most common primary site of tumor was nose (2/4) and the most common histological subtype was infiltrative. The sampled lymph nodes were identified during primary tumor resection, except for 1 patient who had a sentinel lymph node biopsy performed as a surgeon individual decision. One patient had hematogenous spread to the pleura, diagnosed 5 years after diagnosis. In summary, this study adds new data to the current literature in metastatic primary cutaneous basal cell carcinomas and highlights the importance of early diagnosis and appropriate surgical excision in an effort to prevent local advanced disease, recurrence and lymphovascular dissemination.
- Subjects :
- Aged
Carcinoma, Basal Cell diagnosis
Carcinoma, Basal Cell secondary
Carcinoma, Basal Cell surgery
Female
Head and Neck Neoplasms diagnosis
Head and Neck Neoplasms pathology
Head and Neck Neoplasms surgery
Humans
Male
Middle Aged
Neoplasm Recurrence, Local prevention & control
Prevalence
Retrospective Studies
Skin pathology
Skin Neoplasms diagnosis
Skin Neoplasms pathology
Skin Neoplasms surgery
Carcinoma, Basal Cell epidemiology
Head and Neck Neoplasms epidemiology
Neoplasm Recurrence, Local epidemiology
Skin Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-069X
- Volume :
- 313
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archives of dermatological research
- Publication Type :
- Academic Journal
- Accession number :
- 32776227
- Full Text :
- https://doi.org/10.1007/s00403-020-02120-y