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Survival results of 3786 patients with stage I or II laryngeal squamous cell carcinoma: a study based on a propensity score.

Survival results of 3786 patients with stage I or II laryngeal squamous cell carcinoma: a study based on a propensity score.

Authors :
Carvalho GB
Kohler HF
Lira RB
Vartanian JG
Kowalski LP
Source :
Brazilian journal of otorhinolaryngology [Braz J Otorhinolaryngol] 2022 May-Jun; Vol. 88 (3), pp. 337-344. Date of Electronic Publication: 2020 Jul 19.
Publication Year :
2022

Abstract

Introduction: Laryngeal squamous cell carcinoma is the second most prevalent malignancy among head and neck tumors, and the treatment of patients with stage I or II disease can be performed with surgery or radiation therapy. National population studies describing therapeutic results comparing these modalities are unusual, but they can be very important to direct treatment guidelines.<br />Objective: To evaluate the survival results of patients with laryngeal squamous cell carcinoma at clinical stages I or II, according to the main therapeutic modalities used.<br />Methods: Cross-sectional, population-based study using the database of Fundação Oncocentro de São Paulo from January 2000 to March 2019. Inclusion criteria were patients with laryngeal squamous cell carcinoma in clinical stages cT1-2N0. To compensate for the non-random allocation of patients and the imbalance between confounding variables between groups, we used the propensity score methodology.<br />Results: A total of 3786 patients met the inclusion criteria. Regarding the cT stage, there were 2171 patients (57.3%) with cT1 tumors. Patients in the public health system had a longer time between diagnosis and treatment (p < 0.001). The analysis by propensity score showed that patients treated with surgery had a tendency towards better disease-specific survival (p  = 0.012). Comparing radiotherapy alone versus its combination with radiochemotherapy, radiotherapy alone showed a tendency towards a better survival rate (p < 0.001).<br />Conclusion: Analysis by propensity score identified better results for disease-specific survival in patients with laryngeal squamous cell carcinoma at clinical stages I and II treated by surgery when compared to radiotherapy.<br /> (Copyright © 2020 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.)

Details

Language :
English
ISSN :
1808-8686
Volume :
88
Issue :
3
Database :
MEDLINE
Journal :
Brazilian journal of otorhinolaryngology
Publication Type :
Academic Journal
Accession number :
32771434
Full Text :
https://doi.org/10.1016/j.bjorl.2020.06.007