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Pseudolymphomatous Atypical Fibroxanthoma.
- Source :
-
The American Journal of dermatopathology [Am J Dermatopathol] 2020 Dec; Vol. 42 (12), pp. 972-976. - Publication Year :
- 2020
-
Abstract
- Atypical fibroxanthoma is a rare mesenchymal skin tumor of intermediate malignancy that typically occurs on sun-damaged skin of elderly patients. Histologically, it is composed of pleomorphic cells with hyperchromatic nuclei and abundant cytoplasm, commonly arranged in a spindle cell pattern. Different histologic variants have been described during the past years. We present a case of atypical fibroxanthoma containing a dense inflammatory infiltrate, which in conjunction with the existence of immunoblast-like and Reed-Sternberg-like neoplastic cells could be misinterpreted as a lymphoid neoplasm. Immunohistochemical studies revealed strong positivity of tumor cells for CD10 and negativity for cytokeratins, p63, p40, S100, SOX10, ERG, actin, desmin, B and T-cell markers, BCL6, CD15, and CD30. The inflammatory infiltrate contained a mixed reactive T- and B-cell population with negative T-cell receptor and immunoglobulin heavy rearrangements. We discuss the differential diagnosis of this entity in which clinical, immunohistochemical, and molecular features are essential to avoid the diagnosis of a lymphoproliferative disease.
- Subjects :
- Aged, 80 and over
Biomarkers, Tumor analysis
Biomarkers, Tumor genetics
Biopsy
Diagnosis, Differential
Gene Rearrangement, T-Lymphocyte
Genes, Immunoglobulin Heavy Chain
Genes, T-Cell Receptor
Humans
Immunohistochemistry
Male
Neoplasms, Fibrous Tissue genetics
Neoplasms, Fibrous Tissue immunology
Polymerase Chain Reaction
Predictive Value of Tests
Pseudolymphoma genetics
Pseudolymphoma immunology
Skin Neoplasms genetics
Skin Neoplasms immunology
Neoplasms, Fibrous Tissue pathology
Pseudolymphoma pathology
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1533-0311
- Volume :
- 42
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The American Journal of dermatopathology
- Publication Type :
- Report
- Accession number :
- 32769551
- Full Text :
- https://doi.org/10.1097/DAD.0000000000001761