Back to Search
Start Over
Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research.
- Source :
-
Reviews of physiology, biochemistry and pharmacology [Rev Physiol Biochem Pharmacol] 2022; Vol. 183, pp. 157-176. - Publication Year :
- 2022
-
Abstract
- The intracellular Ca <superscript>2+</superscript> concentration is mainly controlled by Ca <superscript>2+</superscript> channels. These channels form complexes with K <superscript>+</superscript> channels, which function to amplify Ca <superscript>2+</superscript> flux. In cancer cells, voltage-gated/voltage-dependent Ca <superscript>2+</superscript> channels and non-voltage-gated/voltage-independent Ca <superscript>2+</superscript> channels have been reported to interact with K <superscript>+</superscript> channels such as Ca <superscript>2+</superscript> -activated K <superscript>+</superscript> channels and voltage-gated K <superscript>+</superscript> channels. These channels are activated by an increase in cytosolic Ca <superscript>2+</superscript> concentration or by membrane depolarization, which induces membrane hyperpolarization, increasing the driving force for Ca <superscript>2+</superscript> flux. These complexes, composed of K <superscript>+</superscript> and Ca <superscript>2+</superscript> channels, are regulated by several molecules including lipids (ether lipids and cholesterol), proteins (e.g. STIM), receptors (e.g. S1R/SIGMAR1), and peptides (e.g. LL-37) and can be targeted by monoclonal antibodies, making them novel targets for cancer research.<br /> (© 2020. Springer Nature Switzerland AG.)
Details
- Language :
- English
- ISSN :
- 0303-4240
- Volume :
- 183
- Database :
- MEDLINE
- Journal :
- Reviews of physiology, biochemistry and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 32767122
- Full Text :
- https://doi.org/10.1007/112_2020_24