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Fusapyrone A, a γ -pyrone derived from a desert Fusarium sp.
- Source :
-
Journal of Asian natural products research [J Asian Nat Prod Res] 2021 May; Vol. 23 (5), pp. 504-511. Date of Electronic Publication: 2020 Aug 07. - Publication Year :
- 2021
-
Abstract
- In this work, we isolated and characterized fusapyrone A ( 1 ), a new γ -pyrone derivative, along with six previously described compounds from the rice fermentation of Fusarium sp. CPCC 401218, a fungus collected from the desert. The structure of 1 was characterized using various spectroscopic analyses, such as MS, IR, 1D, and 2D NMR. The absolute configuration of 1 was determined through the use of <superscript>13</superscript> C NMR chemical shifts, electronic circular dichroism (ECD) and optical rotation (OR) calculations. Compound 1 was found to have weak antiproliferative activity for Hela cells, with an IC <subscript>50</subscript> of 50.6 μM.[Formula: see text].
- Subjects :
- HeLa Cells
Humans
Molecular Structure
Fusarium
Pyrones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2213
- Volume :
- 23
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of Asian natural products research
- Publication Type :
- Academic Journal
- Accession number :
- 32762359
- Full Text :
- https://doi.org/10.1080/10286020.2020.1794857