Back to Search Start Over

Bone lesions in hairy cell leukemia: Diagnosis and treatment.

Authors :
Robak P
Jesionek-Kupnicka D
Kupnicki P
Polliack A
Robak T
Source :
European journal of haematology [Eur J Haematol] 2020 Dec; Vol. 105 (6), pp. 682-691. Date of Electronic Publication: 2020 Aug 19.
Publication Year :
2020

Abstract

Skeletal involvement is a rare complication of hairy cell leukemia (HCL) with an incidence of approximately 3%. Bone lesions are commonly lytic, and the most common sites of involvement are the femoral head and neck. Skeletal involvement is typically associated with high tumor burden and bone marrow infiltration. However, isolated cases of skeletal disease without splenomegaly or bone marrow involvement are occasionally reported. This review focuses on skeletal lesions in HCL, particularly the pathogenesis, clinical symptoms, diagnostic methods, and treatment approach. A literature review of the MEDLINE database for articles in English concerning hairy cell leukemia, skeletal symptoms, bone involvement was conducted via PubMed. Publications from January 1970 to May 2020 were scrutinized. Additional relevant publications were obtained by reviewing the references from the chosen articles.<br /> (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1600-0609
Volume :
105
Issue :
6
Database :
MEDLINE
Journal :
European journal of haematology
Publication Type :
Academic Journal
Accession number :
32757401
Full Text :
https://doi.org/10.1111/ejh.13505