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A nontargeted approach to determine the authenticity of Ginkgo biloba L. plant materials and dried leaf extracts by liquid chromatography-high-resolution mass spectrometry (LC-HRMS) and chemometrics.

Authors :
Cruz MB
Place BJ
Wood LJ
Urbas A
Wasik A
de Carvalho Rocha WF
Source :
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2020 Oct; Vol. 412 (25), pp. 6969-6982. Date of Electronic Publication: 2020 Aug 05.
Publication Year :
2020

Abstract

The lack of stringent regulations regarding raw materials for herbal supplements used for medicinal purposes has been a constant challenge in the industry. Ginkgo biloba L. leaf extracts attract consumers because of the supposed positive effect on mental performance and memory. Supplements are produced using dried leaf materials and standardized leaf extracts such as EGb 761. Adulteration of Ginkgo biloba L. plants and extracts are becoming more and more common practice due to economically driven motivation from increasing demand in the market and the high cost of raw materials and production. Reinforcement in quality control (QC) to avoid adulterations is necessary to ensure the efficacy of the supplements. In this study, liquid chromatography-high-resolution mass spectrometry (LC-HRMS) was used with principal component analysis (PCA) as an unsupervised exploratory method to analyze, identify, and evaluate the adulterated Ginkgo biloba L. plant materials and dried leaf extracts using the PCA scores and loadings obtained and compound identification.

Details

Language :
English
ISSN :
1618-2650
Volume :
412
Issue :
25
Database :
MEDLINE
Journal :
Analytical and bioanalytical chemistry
Publication Type :
Academic Journal
Accession number :
32757063
Full Text :
https://doi.org/10.1007/s00216-020-02830-2