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Isoflavones from the seedpods of Tephrosia vogelii and pyrazoisopongaflavone with anti-inflammatory effects.
- Source :
-
Fitoterapia [Fitoterapia] 2020 Oct; Vol. 146, pp. 104695. Date of Electronic Publication: 2020 Aug 01. - Publication Year :
- 2020
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Abstract
- Phytochemical investigation of Tephrosia vogelii seedpods led to the isolation of twelve compounds: vogelisoflavone A (1), vogelisoflavone B (2), isopongaflavone (3), onogenin, luteolin, 4',7-dihydroxy-3'-methoxyflavanone, trans-p-hydroxycinnamic acid, tephrosin, 2-methoxygliricidol, dehydrorotenone, 6a,12a-dehydro-α-toxicarol and pinoresinol. Compounds 1 and 2 are reported as new natural products. Isopongaflavone (3) was structurally modified using hydrazine to pyrazoisopongaflavone (4). These compounds were characterized based on their NMR and HRESIMS data. Further, four compounds (1-4) were evaluated for their anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPS-stimulated PBMCs with the compounds at a concentration of 100 μM suppressed the secretion of interleukin IL-1β interferon-gamma (IFN-γ), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-α).<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships which have, or could be perceived to have, influenced the work reported in this article.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Anti-Inflammatory Agents isolation & purification
Cells, Cultured
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Interferon-gamma
Interleukin-1beta
Isoflavones isolation & purification
Kenya
Molecular Structure
Phytochemicals isolation & purification
Phytochemicals pharmacology
Tumor Necrosis Factor-alpha
Anti-Inflammatory Agents pharmacology
Isoflavones pharmacology
Leukocytes, Mononuclear drug effects
Tephrosia chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 146
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 32750400
- Full Text :
- https://doi.org/10.1016/j.fitote.2020.104695