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Impact of vaccine type on HIV-1 vaccine elicited antibody durability and B cell gene signature.
- Source :
-
Scientific reports [Sci Rep] 2020 Aug 03; Vol. 10 (1), pp. 13031. Date of Electronic Publication: 2020 Aug 03. - Publication Year :
- 2020
-
Abstract
- Efficacious HIV-1 vaccination requires elicitation of long-lived antibody responses. However, our understanding of how different vaccine types elicit durable antibody responses is lacking. To assess the impact of vaccine type on antibody responses, we measured IgG isotypes against four consensus HIV antigens from 2 weeks to 10 years post HIV-1 vaccination and used mixed effects models to estimate half-life of responses in four human clinical trials. Compared to protein-boosted regimens, half-lives of gp120-specific antibodies were longer but peak magnitudes were lower in Modified Vaccinia Ankara (MVA)-boosted regimens. Furthermore, gp120-specific B cell transcriptomics from MVA-boosted and protein-boosted vaccines revealed a distinct signature at a peak (2 weeks after last vaccination) including CD19, CD40, and FCRL2-5 activation along with increased B cell receptor signaling. Additional analysis revealed contributions of RIG-I-like receptor pathway and genes such as SMAD5 and IL-32 to antibody durability. Thus, this study provides novel insights into vaccine induced antibody durability and B-cell receptor signaling.
- Subjects :
- Antibody Formation immunology
Clinical Trials as Topic
Gene Expression Regulation
Half-Life
Humans
Immunization, Secondary
Linear Models
Lymphocyte Activation immunology
Receptors, Antigen, B-Cell metabolism
Signal Transduction
Vaccination
Vaccinia virus immunology
AIDS Vaccines immunology
B-Lymphocytes immunology
Gene Expression Profiling
HIV Antibodies immunology
HIV Infections genetics
HIV Infections immunology
HIV-1 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32747654
- Full Text :
- https://doi.org/10.1038/s41598-020-69007-w