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Role of Biologics in Chronic Rhinosinusitis With Nasal Polyposis: State of the Art Review.
- Source :
-
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2021 Jan; Vol. 164 (1), pp. 57-66. Date of Electronic Publication: 2020 Aug 04. - Publication Year :
- 2021
-
Abstract
- Objective: To review the current literature regarding the role of biologics in the treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP).<br />Data Sources: PubMed/MEDLINE, EMBASE, Cochrane Review, ClinicalTrials.gov.<br />Review Methods: We conducted a comprehensive review of the literature on clinical studies investigating the efficacy of emerging biologics in CRSwNP, with a focus on randomized controlled trials.<br />Conclusions: There appears to be promising evidence to support the safety and efficacy of biologics in CRSwNP with and without asthma for select patients. However, additional large-scale randomized studies with longer follow-up are necessary to determine which patients would benefit the most from these novel systemic treatments.<br />Implications for Practice: Chronic rhinosinusitis with nasal polyposis refractory to medical and surgical therapy remains a challenging clinical problem for otolaryngologists. However, emerging biologic therapies may offer a new therapeutic option for such patients with recalcitrant disease.
Details
- Language :
- English
- ISSN :
- 1097-6817
- Volume :
- 164
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 32746710
- Full Text :
- https://doi.org/10.1177/0194599820939964