Advances in the Medical Treatment of Cushing Disease.

Medical therapy has an adjunctive role in management of Cushing disease. Medical therapy is recommended for patients who received pituitary radiotherapy and are awaiting its salutary effects. Medications are used preoperatively to stabilize the condition of seriously ill patients before surgery. Medical therapy is used to control hypercortisolism in patients with uncertain tumor location. Medical therapies available for management of patients with Cushing disease include steroidogenesis inhibitors, centrally acting agents, and glucocorticoid receptor antagonists. All agents require careful monitoring to optimize clinical effectiveness and manage adverse effects. Novel agents in development may expand the armamentarium for management of this condition.
Competing Interests: Disclosure N.A. Tritos has received institution-directed research support from Ipsen and Novartis. B.M.K. Biller has received institution-directed research support from Millendo, Novartis, and Strongbridge and occasional consulting honoraria from Novartis and Strongbridge.
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