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Neuroprotective effects of melatonin against neurotoxicity induced by intranasal sodium dimethyldithiocarbamate administration in mice.
- Source :
-
Neurotoxicology [Neurotoxicology] 2020 Sep; Vol. 80, pp. 144-154. Date of Electronic Publication: 2020 Jul 30. - Publication Year :
- 2020
-
Abstract
- Exposure to fungicide ziram (zinc dimethyldithiocarbamate) has been associated with increased incidence of Parkinson's disease (PD). We recently demonstrated that the intranasal (i.n.) administration of sodium dimethyldithiocarbamate (NaDMDC, a more soluble salt than ziram) induces PD-like behavioral and neurochemical alterations in mice. We now investigated the putative neuroprotective effects of melatonin on behavioral dificits and neurochemical alterations induced by i.n. NaDMDC. Melatonin treatment (3, 10 or 30 mg/kg, i.p.) was given 1 h before NaDMDC administration (1 mg/nostril) during 4 consecutive days and we evaluated early (up to 7 days) and late (up to 35 days) NaDMDC-induced behavioral and neurochemical alterations. Melatonin treatment protected against early motor and general neurological impairments observed in the open field and neurological score of severity, respectively, and late deficits in rotarod test. Melatonin prevented the NaDMDC-induced alterations in the striatal tyrosine hydroxylase immunocontent. Melatonin also protected against increased levels of oxidative stress markers (4-hydroxynonenal and 3-nitrotyrosine) in the striatum, as well as the NaDMDC-induced increase of 4-hydroxynonenal and TNF, markers of oxidative stress and inflammation, respectively, in the olfactory bulb. These results further detail the mechanisms underlying NaDMDC toxicity and demonstrate the neuroprotective effects of melatonin against the neuronal damage induced by NaDMDC.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Administration, Intranasal
Animals
Behavior, Animal drug effects
Brain metabolism
Brain physiopathology
Dimethyldithiocarbamate
Disease Models, Animal
Dopaminergic Neurons metabolism
Dopaminergic Neurons pathology
Male
Mice
Motor Activity drug effects
Neurotoxicity Syndromes etiology
Neurotoxicity Syndromes metabolism
Neurotoxicity Syndromes physiopathology
Nitrosative Stress drug effects
Oxidative Stress drug effects
Brain drug effects
Dopaminergic Neurons drug effects
Melatonin pharmacology
Neuroprotective Agents pharmacology
Neurotoxicity Syndromes prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9711
- Volume :
- 80
- Database :
- MEDLINE
- Journal :
- Neurotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 32738267
- Full Text :
- https://doi.org/10.1016/j.neuro.2020.07.008