Recent Advancements in CD47 Signal Transduction Pathways Involved in Vascular Diseases.

Authors :: Dou M
Chen Y
Hu J
Ma D
Xing Y
Source :: BioMed research international [Biomed Res Int] 2020 Jul 15; Vol. 2020, pp. 4749135. Date of Electronic Publication: 2020 Jul 15 (Print Publication: 2020).
Publication Year :: 2020
Abstract: Cardiovascular and cerebrovascular diseases caused by atherosclerosis have a high disability rate and reduce the quality of life of the population. Therefore, understanding the mechanism of atherosclerosis and its control may interfere with the progression of atherosclerosis and thus control the occurrence of diseases closely related to atherosclerosis. TSP-1 is a factor that has been found to have an antiangiogenic effect, and CD47, as the receptor of TSP-1, can participate in the regulation of antiangiogenesis of atherosclerosis. VEGF is an important regulator of angiogenesis, and TSP-1/CD47 can cause VEGF and its downstream expression. Therefore, the TSP-1/CD47/VEGF/VEGFR2 signal may have an important influence on atherosclerosis. In addition, some inflammatory factors, such as IL-1 and NLRP3, can also affect atherosclerosis. This review will be expounded focusing on the pathogenesis and influencing factors of atherosclerosis.<br />Competing Interests: The authors declare that they have no conflicts of interest.<br /> (Copyright © 2020 Manman Dou et al.)

Subjects :: Animals
Cytokines metabolism
Humans
Inflammation pathology
Molecular Targeted Therapy
Vascular Diseases immunology
CD47 Antigen metabolism
Signal Transduction
Vascular Diseases metabolism

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