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Fingernail cortisol - State of research and future directions.
- Source :
-
Frontiers in neuroendocrinology [Front Neuroendocrinol] 2020 Jul; Vol. 58, pp. 100855. Date of Electronic Publication: 2020 Jul 27. - Publication Year :
- 2020
-
Abstract
- The extraction of cortisol from fingernails represents a recent advancement in the retrospective, long-term assessment of hypothalamic-pituitaryadrenal (HPA) axis activity: Fingernail cortisol has the potential to overcome some of the major disadvantages of established HPA axis markers. However, the introduction of any novel methodology also raises certain caveats. This review provides a comprehensive summary of the current state of research on fingernail cortisol. It identifies a number of strengths of his novel methodology (e.g., its high feasibility), while also pointing out open questions which currently challenge the interpretability of fingernail findings, in particular regarding the time period of cortisol secretion reflected in fingernail samples, as well as regarding potential determinants or confounders of fingernail cortisol (e.g. sociodemographic, lifestyle, or health characteristics). Clarification of these issues in the context of further methodological studies is necessary to validate the use of fingernail cortisol as a retrospective marker of HPA axis activity.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Biomarkers analysis
Biomarkers metabolism
Biomedical Research methods
Biomedical Research standards
Diagnostic Techniques, Endocrine standards
Humans
Hydrocortisone metabolism
Nails metabolism
Predictive Value of Tests
Reproducibility of Results
Stress, Psychological diagnosis
Stress, Psychological metabolism
Biomedical Research trends
Diagnostic Techniques, Endocrine trends
Hydrocortisone analysis
Nails chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6808
- Volume :
- 58
- Database :
- MEDLINE
- Journal :
- Frontiers in neuroendocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 32730860
- Full Text :
- https://doi.org/10.1016/j.yfrne.2020.100855