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Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study.
- Source :
-
The journal of headache and pain [J Headache Pain] 2020 Jul 29; Vol. 21 (1), pp. 94. Date of Electronic Publication: 2020 Jul 29. - Publication Year :
- 2020
-
Abstract
- Introduction: Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality.<br />Methods: Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demographic data, clinical variables and laboratory abnormalities. We used multivariate regression analysis.<br />Results: During the study period, 576 patients were included, aged 67.2 (SD: 14.7), and 250/576 (43.3%) being female. Presence of headache was described by 137 (23.7%) patients. The all-cause in-hospital mortality rate was 127/576 (20.0%). In the multivariate analysis, patients with headache had a lower risk of mortality (OR: 0.39, 95% CI: 0.17-0.88, p = 0.007). After adjusting for multiple comparisons in a multivariate analysis, variables that were independently associated with a higher odds of having headache in COVID-19 patients were anosmia, myalgia, female sex and fever; variables that were associated with a lower odds of having headache were younger age, lower score on modified Rankin scale, and, regarding laboratory variables on admission, increased C-reactive protein, abnormal platelet values, lymphopenia and increased D-dimer.<br />Conclusion: Headache is a frequent symptom in COVID-19 patients and its presence is an independent predictor of lower risk of mortality in COVID-19 hospitalized patients.
- Subjects :
- Aged
Aged, 80 and over
COVID-19
Coronavirus Infections complications
Coronavirus Infections mortality
Female
Headache etiology
Headache mortality
Hospitalization
Humans
Male
Middle Aged
Pandemics
Pneumonia, Viral complications
Pneumonia, Viral mortality
Prognosis
Retrospective Studies
SARS-CoV-2
Survival Rate
Betacoronavirus
Coronavirus Infections epidemiology
Headache epidemiology
Hospital Mortality
Pneumonia, Viral epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1129-2377
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The journal of headache and pain
- Publication Type :
- Academic Journal
- Accession number :
- 32727345
- Full Text :
- https://doi.org/10.1186/s10194-020-01165-8