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Severe Acute Respiratory Syndrome Coronavirus 2: From Gene Structure to Pathogenic Mechanisms and Potential Therapy.
- Source :
-
Frontiers in microbiology [Front Microbiol] 2020 Jul 03; Vol. 11, pp. 1576. Date of Electronic Publication: 2020 Jul 03 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerging respiratory virus with high morbidity, which was named coronavirus disease 2019 (COVID-19) by World Health Organization (WHO). COVID-19 has triggered a series of threats to global public health. Even worse, new cases of COVID-19 infection are still increasing rapidly. Therefore, it is imperative that various effective vaccines and drugs should be developed to prevent and treat COVID-19 and reduce the serious impact on human beings. For this purpose, detailed information about the pathogenesis of COVID-19 at the cellular and molecular levels is urgently needed. In this review, we summarized the current understanding on gene structure, protein function, and pathogenic mechanisms of SARS-CoV-2. Based on the above, we refined the correlations among gene structure, protein function, and pathogenic mechanisms of SARS-CoV-2. Importantly, we further discussed potential therapeutic targets, aiming to accelerate the advanced design and development of vaccines and therapeutic drugs against COVID-19.<br /> (Copyright © 2020 Wu, Yuan, Wang, Gu, Li, Xiang, Tang and Sun.)
Details
- Language :
- English
- ISSN :
- 1664-302X
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Frontiers in microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 32719672
- Full Text :
- https://doi.org/10.3389/fmicb.2020.01576