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Oxytocin Ameliorates Impaired Behaviors of High Fat Diet-Induced Obese Mice.
- Source :
-
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2020 Jul 03; Vol. 11, pp. 379. Date of Electronic Publication: 2020 Jul 03 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Excessive intake of fat is a major risk factor for lifestyle-related diseases such as heart disease and also affects brain function such as object recognition memory, social recognition, anxiety behavior, and depression-like behavior. Although oxytocin (OXT) has been reported to improve object recognition, social recognition, anxiety behavior, and depression-like behavior in specific conditions, previous studies did not explore the impact of OXT in high-fat diet (HFD)-fed mice. Furthermore, it remains unclear whether intake of HFD affects OXT/oxytocin receptor (OXTR) in the brain. Here, we demonstrated that peripheral OXT administration improves not only social recognition but also object recognition and depressive-like behavior in HFD-fed mice. In contrast, peripheral OXT administration to HFD-fed male mice increased fear and anxiety-related behavior. In addition, we observed that intake of HFD decreased OXTR and c-fos mRNA expression in the hippocampus, specifically. Furthermore, peripheral OXT administration increased OXT mRNA expression in the hypothalamus. Altogether, these findings suggest that OXT has the potential to improve various recognition memory processes via peripheral administration but also has side effects that increase fear-related behavior in males.<br /> (Copyright © 2020 Hayashi, Kasahara, Hidema, Fukumitsu, Nakagawa and Nishimori.)
- Subjects :
- Animals
Anxiety physiopathology
Depression physiopathology
Diet, High-Fat
Fear physiology
Hypothalamus drug effects
Hypothalamus physiology
Male
Memory drug effects
Mice, Inbred C57BL
Neurons drug effects
Neurons physiology
Oxytocin administration & dosage
Receptors, Oxytocin physiology
Social Behavior
Behavior, Animal physiology
Memory physiology
Obesity physiopathology
Obesity psychology
Oxytocin physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-2392
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Frontiers in endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 32719656
- Full Text :
- https://doi.org/10.3389/fendo.2020.00379