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Effects on Melanoma Cell Lines Suggest No Significant Risk of Melanoma Under Cladribine Treatment.

Effects on Melanoma Cell Lines Suggest No Significant Risk of Melanoma Under Cladribine Treatment.

Authors :
Lebrun-Frenay C
Berestjuk I
Cohen M
Tartare-Deckert S
Source :
Neurology and therapy [Neurol Ther] 2020 Dec; Vol. 9 (2), pp. 599-604. Date of Electronic Publication: 2020 Jul 25.
Publication Year :
2020

Abstract

Cladribine is an oral synthetic purine analog that depletes lymphocytes and induces a dose-dependent reduction of T and B cells. It was approved for the therapy of highly active relapsing-remitting multiple sclerosis. Given cladribine's mechanism of action, an increased risk of malignancies was suspected from the number of cancers that occurred in the 3.5 mg/kg-treated arm (CLARITY study). We showed that cladribine inhibits cell proliferation on three melanoma cell lines tested, irrespectively of their mutational oncogenic status and invasive/metastatic potential. Aggregated safety data demonstrated that the risk of melanoma is not confirmed.

Details

Language :
English
ISSN :
2193-8253
Volume :
9
Issue :
2
Database :
MEDLINE
Journal :
Neurology and therapy
Publication Type :
Academic Journal
Accession number :
32712904
Full Text :
https://doi.org/10.1007/s40120-020-00204-5