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Effects on Melanoma Cell Lines Suggest No Significant Risk of Melanoma Under Cladribine Treatment.
Effects on Melanoma Cell Lines Suggest No Significant Risk of Melanoma Under Cladribine Treatment.
- Source :
-
Neurology and therapy [Neurol Ther] 2020 Dec; Vol. 9 (2), pp. 599-604. Date of Electronic Publication: 2020 Jul 25. - Publication Year :
- 2020
-
Abstract
- Cladribine is an oral synthetic purine analog that depletes lymphocytes and induces a dose-dependent reduction of T and B cells. It was approved for the therapy of highly active relapsing-remitting multiple sclerosis. Given cladribine's mechanism of action, an increased risk of malignancies was suspected from the number of cancers that occurred in the 3.5 mg/kg-treated arm (CLARITY study). We showed that cladribine inhibits cell proliferation on three melanoma cell lines tested, irrespectively of their mutational oncogenic status and invasive/metastatic potential. Aggregated safety data demonstrated that the risk of melanoma is not confirmed.
Details
- Language :
- English
- ISSN :
- 2193-8253
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neurology and therapy
- Publication Type :
- Academic Journal
- Accession number :
- 32712904
- Full Text :
- https://doi.org/10.1007/s40120-020-00204-5