Occult Hepatitis B Virus Infection in Immunized Infants Born to Untreated and Tenofovir-Treated Highly Viremic Mothers.

Authors :: Hsu HY
Chen HL
Wu JF
Ni YH
Chang KC
Chiang CL
Lee CN
Zhao LL
Lai MW
Mu SC
Wen WH
Lin LH
Chang MH
Source :: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2021 Jul; Vol. 19 (7), pp. 1494-1496. Date of Electronic Publication: 2020 Jul 23.
Publication Year :: 2021
Abstract: Tenofovir disoproxil fumurate (TDF) therapy during late pregnancy in highly viremic mothers can reduce residual overt hepatitis B virus (HBV) infections of their infants that occur despite immunoprophylaxis. <superscript>1</superscript> <superscript>,</superscript> <superscript>2</superscript> Occult HBV infection (OBI) has been defined as the presence of HBV DNA in liver or sera in subjects seronegative for hepatitis B surface antigen (HBsAg). <superscript>3</superscript> OBI has been found in varying proportions of immunized infants born to HBsAg-positive mothers. <superscript>4-6</superscript> We aimed to investigate the impact of maternal TDF therapy during pregnancy on vertically acquired OBI.<br /> (Copyright © 2021 AGA Institute. Published by Elsevier Inc. All rights reserved.)

Subjects :: DNA, Viral
Female
Hepatitis B Surface Antigens
Humans
Infant
Infectious Disease Transmission, Vertical prevention & control
Mothers
Pregnancy
Tenofovir therapeutic use
Hepatitis B prevention & control
Hepatitis B virus genetics

Language :: English
ISSN :: 1542-7714
Volume :: 19
Issue :: 7
Database :: MEDLINE
Journal :: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Publication Type :: Academic Journal
Accession number :: 32712392
Full Text :: https://doi.org/10.1016/j.cgh.2020.07.041

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