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Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 17; Vol. 21 (14). Date of Electronic Publication: 2020 Jul 17. - Publication Year :
- 2020
-
Abstract
- Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to develop ligands for CB1 and CB2, resulting in hundreds of phyto- and synthetic cannabinoids which have shown varying affinities relevant for the treatment of various diseases. However, only a few of these ligands are clinically used. Recently, more detailed structural information for cannabinoid receptors was revealed thanks to the powerfulness of cryo-electron microscopy, which now can accelerate structure-based drug discovery. At the same time, novel peptide-type cannabinoids from animal sources have arrived at the scene, with their potential in vivo therapeutic effects in relation to cannabinoid receptors. From a natural products perspective, it is expected that more novel cannabinoids will be discovered and forecasted as promising drug leads from diverse natural sources and species, such as animal venoms which constitute a true pharmacopeia of toxins modulating diverse targets, including voltage- and ligand-gated ion channels, G protein-coupled receptors such as CB1 and CB2, with astonishing affinity and selectivity. Therefore, it is believed that discovering novel cannabinoids starting from studying the biodiversity of the species living on planet earth is an uncharted territory.
- Subjects :
- Animals
Biological Products chemistry
Cannabinoid Receptor Agonists chemistry
Cannabinoid Receptor Antagonists chemistry
Cannabinoids chemistry
Drug Discovery
Humans
Molecular Docking Simulation
Peptides chemistry
Receptors, Cannabinoid chemistry
Biological Products pharmacology
Cannabinoid Receptor Agonists pharmacology
Cannabinoid Receptor Antagonists pharmacology
Cannabinoids pharmacology
Peptides pharmacology
Receptors, Cannabinoid metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32709050
- Full Text :
- https://doi.org/10.3390/ijms21145064