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Nutrients, Mitochondrial Function, and Perinatal Health.
- Source :
-
Nutrients [Nutrients] 2020 Jul 21; Vol. 12 (7). Date of Electronic Publication: 2020 Jul 21. - Publication Year :
- 2020
-
Abstract
- Mitochondria are active independent organelles that not only meet the cellular energy requirement but also regulate central cellular activities. Mitochondria can play a critical role in physiological adaptations during pregnancy. Differences in mitochondrial function have been found between healthy and complicated pregnancies. Pregnancy signifies increased nutritional requirements to support fetal growth and the metabolism of maternal and fetal tissues. Nutrient availability regulates mitochondrial metabolism, where excessive macronutrient supply could lead to oxidative stress and contribute to mitochondrial dysfunction, while micronutrients are essential elements for optimal mitochondrial processes, as cofactors in energy metabolism and/or as antioxidants. Inadequate macronutrient and micronutrient consumption can result in adverse pregnancy outcomes, possibly through mitochondrial dysfunction, by impairing energy supply, one-carbon metabolism, biosynthetic pathways, and the availability of metabolic co-factors which modulate the epigenetic processes capable of establishing significant short- and long-term effects on infant health. Here, we review the importance of macronutrients and micronutrients on mitochondrial function and its influence on maternal and infant health.
- Subjects :
- Epigenesis, Genetic
Female
Humans
Infant, Newborn
Male
Mitochondria genetics
Oxidative Stress
Vitamins
Eating physiology
Energy Metabolism physiology
Infant Health
Infant Nutritional Physiological Phenomena physiology
Maternal Health
Maternal Nutritional Physiological Phenomena physiology
Maternal-Fetal Exchange physiology
Micronutrients
Mitochondria metabolism
Mitochondria physiology
Nutrients
Nutritional Requirements
Pregnancy metabolism
Pregnancy physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 12
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 32708345
- Full Text :
- https://doi.org/10.3390/nu12072166