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Neurochemical, neurobehavioral and histochemical effects of therapeutic dose of l-dopa on striatal neurons in rats: Protective effect of virgin coconut oil.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Oct; Vol. 130, pp. 110473. Date of Electronic Publication: 2020 Jul 21. - Publication Year :
- 2020
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Abstract
- Despite the fact that levodopa has proven its effectiveness in treating the symptoms of Parkinson's disease (PD), increasing concerns have emerged about its possible long-term toxic effects on dopamine (DA) neurons. The study investigated the possible ameliorative effect of virgin coconut oil against l-dopa- induced neurotoxicity in adult rats. A total number of 40 rats were divided into four groups. Briefly, the first served as control, the second was orally administered virgin coconut oil (1.42 mL/kg), the third group was administered a single daily dose of l-dopa/carbidopa (100/10 mg/kg/day, p.o) and the fourth group pre-treated with virgin coconut oil then administered a single daily dose of l-dopa/carbidopa. The different treatments were extended for 30 days. l-dopa treated group exhibited aggressive behavior and behavioral abnormalities in open field test compared to control group. In addition, l-dopa treatment caused significant increase in the levels of striatal dopamine and norepinephrine and their metabolites with concomitant decrease of serotonin and its metabolite. Moreover, l-dopa treatment increased histamine and GABA levels. In addition, l-dopa treatment induced oxidative stress and energy crisis. The histological and immunohistochemical studies showed that l-dopa caused a remarkable neurodegeneration and increased glial fibrillary acidic protein (GFAP) immunoexpression in the striatal area. Virgin coconut oil co-treatment significantly minimized the harmful effects of l-dopa. In conclusion, the present study revealed that virgin coconut oil provided a notable protection against l-dopa's untoward effects.<br /> (Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- Animals
Behavior, Animal drug effects
Carbidopa toxicity
Corpus Striatum metabolism
Corpus Striatum pathology
Male
Neurons metabolism
Neurons pathology
Parkinson Disease complications
Parkinson Disease drug therapy
Rats, Sprague-Dawley
Coconut Oil administration & dosage
Corpus Striatum drug effects
Levodopa toxicity
Neurons drug effects
Neuroprotective Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 130
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 32707436
- Full Text :
- https://doi.org/10.1016/j.biopha.2020.110473