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PRAME expression in melanocytic proliferations with intermediate histopathologic or spitzoid features.
- Source :
-
Journal of cutaneous pathology [J Cutan Pathol] 2020 Dec; Vol. 47 (12), pp. 1123-1131. Date of Electronic Publication: 2020 Sep 10. - Publication Year :
- 2020
-
Abstract
- Background: PRAME (PReferentially expressed Antigen in MElanoma) has shown utility in distinguishing melanoma from benign melanocytic lesions, but knowledge of its expression pattern in intermediate melanocytic and spitzoid proliferations is limited.<br />Methods: Immunohistochemical expression of PRAME was examined in 112 melanocytic proliferations with intermediate histopathologic or spitzoid features.<br />Results: Any intensity of nuclear PRAME staining in at least 60% of lesional melanocytes was determined as the best threshold for diffuse staining in this cohort. Nearly all non-spitzoid melanomas (23/24; 95.8%) demonstrated diffuse PRAME expression. PRAME was completely negative in 95.6% (43/45) of mitotically-active nevi, traumatized nevi, nevi with persistent/recurrent features, and dysplastic nevi. Most Spitz nevi (15/20) and atypical Spitz tumors (10/13) entirely lacked PRAME expression. One Spitz nevus, one atypical Spitz tumor, and one spitzoid melanoma (1/2) demonstrated diffuse PRAME expression.<br />Conclusions: Although diffuse PRAME expression is generally limited to malignant melanoma, benign Spitz nevi and atypical Spitz tumors can infrequently express diffuse PRAME. PRAME immunohistochemistry can be useful in the evaluation of atypical melanocytic proliferations with intermediate histopathologic features but should be interpreted with caution in the setting of spitzoid neoplasms.<br /> (© 2020 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Carrier Proteins genetics
Cohort Studies
Diagnosis, Differential
Dysplastic Nevus Syndrome genetics
Dysplastic Nevus Syndrome pathology
Female
Humans
Immunohistochemistry methods
Male
Melanoma pathology
Nevus, Epithelioid and Spindle Cell genetics
Nevus, Epithelioid and Spindle Cell pathology
Skin Neoplasms pathology
Tumor Suppressor Proteins genetics
Ubiquitin Thiolesterase genetics
Melanoma, Cutaneous Malignant
Antigens, Neoplasm genetics
Cell Proliferation genetics
Melanocytes pathology
Melanoma genetics
Skin Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0560
- Volume :
- 47
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of cutaneous pathology
- Publication Type :
- Academic Journal
- Accession number :
- 32700786
- Full Text :
- https://doi.org/10.1111/cup.13818