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Glucosamine protects against radiation-induced lung injury via inhibition of epithelial-mesenchymal transition.
- Source :
-
Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Sep; Vol. 24 (18), pp. 11018-11023. Date of Electronic Publication: 2020 Jul 22. - Publication Year :
- 2020
-
Abstract
- Radiotherapy is one of the most important treatments for chest tumours. Although there are plenty of strategies to prevent damage to normal lung tissues, it cannot be avoided with the emergence of radiation-induced lung injury. The purpose of this study was to investigate the potential radioprotective effects of glucosamine, which exerted anti-inflammatory activity in joint inflammation. In this study, we found glucosamine relieved inflammatory response and structural damages in lung tissues after radiation via HE staining. Then, we detected the level of epithelial-mesenchymal transition marker in vitro and in vivo, which we could clearly observe that glucosamine treatment inhibited epithelial-mesenchymal transition. Besides, we found glucosamine could inhibit apoptosis and promote proliferation of normal lung epithelial cells in vitro caused by radiation. In conclusion, our data showed that glucosamine alleviated radiation-induced lung injury via inhibiting epithelial-mesenchymal transition, which indicated glucosamine could be a novel potential radioprotector for radiation-induced lung injury.<br /> (© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
- Subjects :
- Alveolar Epithelial Cells radiation effects
Animals
Anti-Inflammatory Agents pharmacology
Apoptosis drug effects
Colony-Forming Units Assay
Drug Evaluation, Preclinical
Female
Gamma Rays adverse effects
Glucosamine pharmacology
Mice
Mice, Inbred C57BL
Pulmonary Fibrosis etiology
Radiation Pneumonitis etiology
Radiation-Protective Agents pharmacology
Rats
Alveolar Epithelial Cells drug effects
Anti-Inflammatory Agents therapeutic use
Epithelial-Mesenchymal Transition drug effects
Glucosamine therapeutic use
Lung radiation effects
Pulmonary Fibrosis prevention & control
Radiation Injuries, Experimental drug therapy
Radiation Pneumonitis prevention & control
Radiation-Protective Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1582-4934
- Volume :
- 24
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Journal of cellular and molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32700471
- Full Text :
- https://doi.org/10.1111/jcmm.15662