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Pneumonitis from immune checkpoint inhibitors and COVID-19: current concern in cancer treatment.
- Source :
-
Journal for immunotherapy of cancer [J Immunother Cancer] 2020 Jul; Vol. 8 (2). - Publication Year :
- 2020
-
Abstract
- Pneumonitis is a rare but serious adverse event caused by cancer immunotherapy. The diagnosis between COVID-19-induced pneumonia and immunotherapy-induced pneumonitis may be challenging in the era of COVID-19 outbreak. Some clinical symptoms and radiological findings of pneumonitis can be attributed to the coronavirus infection as well as to an immune-related adverse event. Identifying the exact cause of a pneumonitis in patients on treatment with immunotherapy is crucial to promptly start the most appropriate treatment. The proper management of immune checkpoint inhibitors for the risk of pneumonia must take into account a series of parameters. Accurate attention should be payed to symptoms like cough, fever and dyspnea during immunotherapy.<br />Competing Interests: Competing interests: None declared.<br /> (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Betacoronavirus
COVID-19
COVID-19 Testing
CTLA-4 Antigen antagonists & inhibitors
Clinical Laboratory Techniques
Coronavirus Infections immunology
Coronavirus Infections therapy
Diagnosis, Differential
False Negative Reactions
Glucocorticoids therapeutic use
Humans
Immunosuppressive Agents therapeutic use
Lung diagnostic imaging
Pandemics
Pneumonia drug therapy
Pneumonia immunology
Pneumonia, Viral immunology
Pneumonia, Viral therapy
Programmed Cell Death 1 Receptor antagonists & inhibitors
Reverse Transcriptase Polymerase Chain Reaction
SARS-CoV-2
Tomography, X-Ray Computed
Antineoplastic Agents, Immunological adverse effects
Coronavirus Infections diagnosis
Neoplasms drug therapy
Pneumonia chemically induced
Pneumonia diagnosis
Pneumonia, Viral diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 2051-1426
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal for immunotherapy of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 32699182
- Full Text :
- https://doi.org/10.1136/jitc-2020-000952