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Angiotensin-(1-7) Improves Integrated Cardiometabolic Function in Aged Mice.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 20; Vol. 21 (14). Date of Electronic Publication: 2020 Jul 20. - Publication Year :
- 2020
-
Abstract
- Angiotensin (Ang)-(1-7) is a beneficial renin-angiotensin system (RAS) hormone that elicits protective cardiometabolic effects in young animal models of hypertension, obesity, and metabolic syndrome. The impact of Ang-(1-7) on cardiovascular and metabolic outcomes during aging, however, remains unexplored. This study tested the hypothesis that Ang-(1-7) attenuates age-related elevations in blood pressure and insulin resistance in mice. Young adult (two-month-old) and aged (16-month-old) male C57BL/6J mice received Ang-(1-7) (400 ng/kg/min) or saline for six-weeks via a subcutaneous osmotic mini-pump. Arterial blood pressure and metabolic function indices (body composition, insulin sensitivity, and glucose tolerance) were measured at the end of treatment. Adipose and cardiac tissue masses and cardiac RAS, sympathetic and inflammatory marker gene expression were also measured. We found that chronic Ang-(1-7) treatment decreased systolic and mean blood pressure, with a similar trend for diastolic blood pressure. Ang-(1-7) also improved insulin sensitivity in aged mice to levels in young mice, without effects on glucose tolerance or body composition. The blood pressure-lowering effects of Ang-(1-7) in aged mice were associated with reduced sympathetic outflow to the heart. These findings suggest Ang-(1-7) may provide a novel pharmacological target to improve age-related cardiometabolic risk.
- Subjects :
- Aging drug effects
Angiotensin I administration & dosage
Animals
Antihypertensive Agents administration & dosage
Glucose metabolism
Hypertension drug therapy
Hypertension etiology
Hypertension metabolism
Insulin metabolism
Male
Mice, Inbred C57BL
Peptide Fragments administration & dosage
Renin-Angiotensin System drug effects
Angiotensin I pharmacology
Antihypertensive Agents pharmacology
Blood Pressure drug effects
Insulin Resistance
Peptide Fragments pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32698498
- Full Text :
- https://doi.org/10.3390/ijms21145131