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Current status of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus isolated from patients with skin and soft tissue infections in Japan.
- Source :
-
The Journal of dermatology [J Dermatol] 2020 Nov; Vol. 47 (11), pp. 1280-1286. Date of Electronic Publication: 2020 Jul 21. - Publication Year :
- 2020
-
Abstract
- The USA300 clone, which produces Panton-Valentine leukocidin (PVL), is a major pathogenic community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) clone that causes intractable skin infections. Recently, PVL-positive CA-MRSA, including USA300 clones, have emerged in both communities and hospitals in Japan. To prevent an outbreak of PVL-positive MRSA, infected patients should be treated with effective antimicrobial agents at community clinics. Herein, we investigate molecular epidemiological characteristics of PVL-positive MRSA isolated from outpatients with skin and soft tissue infections (SSTI), which are common community-onset infectious diseases. The detection rate of MRSA was 24.9% (362 strains) out of 1455 S. aureus strains isolated between 2013 and 2017. Among the MRSA strains, 15.5% (56 strains) were PVL-positive strains and associated with deep-seated skin infections. Molecular epidemiological analyses of PVL-positive MRSA showed that USA300 was the predominant clone (53.6%, 30 strains) and was identified in Kanto (18 strains), Kagawa (nine strains), Tohoku (two strains) and Hokkaido (one strain). Notably, minocycline and fusidic acid were effective against all PVL-positive MRSA strains. Hence, our data reveals the current status of PVL-positive MRSA isolated from patients with SSTI in Japan. Continuous surveillance of CA-MRSA is necessary to monitor latest prevalence rates and identify effective antimicrobial agents for PVL-positive MRSA strains.<br /> (© 2020 Japanese Dermatological Association.)
- Subjects :
- Anti-Bacterial Agents therapeutic use
Bacterial Toxins
Exotoxins genetics
Humans
Japan epidemiology
Leukocidins genetics
Staphylococcus aureus
Community-Acquired Infections drug therapy
Community-Acquired Infections epidemiology
Methicillin-Resistant Staphylococcus aureus genetics
Soft Tissue Infections drug therapy
Soft Tissue Infections epidemiology
Staphylococcal Infections drug therapy
Staphylococcal Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1346-8138
- Volume :
- 47
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 32696497
- Full Text :
- https://doi.org/10.1111/1346-8138.15506