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A Phase Ib/IIa Study of the Pan-BET Inhibitor ZEN-3694 in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer.
- Source :
-
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Oct 15; Vol. 26 (20), pp. 5338-5347. Date of Electronic Publication: 2020 Jul 21. - Publication Year :
- 2020
-
Abstract
- Purpose: ZEN-3694 is a bromodomain extraterminal inhibitor (BETi) with activity in androgen-signaling inhibitor (ASI)-resistant models. The safety and efficacy of ZEN-3694 plus enzalutamide was evaluated in a phase Ib/IIa study in metastatic castration-resistant prostate cancer (mCRPC).<br />Patients and Methods: Patients had progressive mCRPC with prior resistance to abiraterone and/or enzalutamide. 3+3 dose escalation was followed by dose expansion in parallel cohorts (ZEN-3694 at 48 and 96 mg orally once daily, respectively).<br />Results: Seventy-five patients were enrolled ( N = 26 and 14 in dose expansion at low- and high-dose ZEN-3694, respectively). Thirty (40.0%) patients were resistant to abiraterone, 34 (45.3%) to enzalutamide, and 11 (14.7%) to both. ZEN-3694 dosing ranged from 36 to 144 mg daily without reaching an MTD. Fourteen patients (18.7%) experienced grade ≥3 toxicities, including three patients with grade 3 thrombocytopenia (4%). An exposure-dependent decrease in whole-blood RNA expression of BETi targets was observed (up to fourfold mean difference at 4 hours post-ZEN-3694 dose; P ≤ 0.0001). The median radiographic progression-free survival (rPFS) was 9.0 months [95% confidence interval (CI), 4.6-12.9] and composite median radiographic or clinical progression-free survival (PFS) was 5.5 months (95% CI, 4.0-7.8). Median duration of treatment was 3.5 months (range, 0-34.7+). Lower androgen receptor (AR) transcriptional activity in baseline tumor biopsies was associated with longer rPFS (median rPFS 10.4 vs. 4.3 months).<br />Conclusions: ZEN-3694 plus enzalutamide demonstrated acceptable tolerability and potential efficacy in patients with ASI-resistant mCRPC. Further prospective study is warranted including in mCRPC harboring low AR transcriptional activity.<br /> (©2020 American Association for Cancer Research.)
- Subjects :
- Aged
Aged, 80 and over
Androstenes adverse effects
Antineoplastic Agents administration & dosage
Antineoplastic Agents adverse effects
Antineoplastic Combined Chemotherapy Protocols adverse effects
Benzamides adverse effects
Disease-Free Survival
Drug Resistance, Neoplasm drug effects
Humans
Male
Middle Aged
Neoplasm Metastasis
Nitriles adverse effects
Phenylthiohydantoin adverse effects
Progression-Free Survival
Prostatic Neoplasms, Castration-Resistant pathology
Receptors, Androgen genetics
Treatment Outcome
Androstenes administration & dosage
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Benzamides administration & dosage
Nitriles administration & dosage
Phenylthiohydantoin administration & dosage
Prostatic Neoplasms, Castration-Resistant drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1557-3265
- Volume :
- 26
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Publication Type :
- Academic Journal
- Accession number :
- 32694156
- Full Text :
- https://doi.org/10.1158/1078-0432.CCR-20-1707