Back to Search
Start Over
Rotavirus Disease and Genotype Diversity in Older Children and Adults in Australia.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2022 Jun 15; Vol. 225 (12), pp. 2116-2126. - Publication Year :
- 2022
-
Abstract
- Background: Rotavirus is a major cause of gastroenteritis in children <5 years of age. The disease burden in older children, adults, and the elderly is underappreciated. This study describes rotavirus disease and genotypic diversity in the Australian population comprising children ≥5 years of age and adults.<br />Methods: Rotavirus positive fecal samples were collected from laboratories Australia-wide participating in the Australian Rotavirus Surveillance Program between 2010 and 2018. Rotavirus samples were genotyped using a heminested multiplex reverse-transcription polymerase chain reaction. Notification data from the National Notifiable Diseases Surveillance System were also analyzed.<br />Results: Rotavirus disease was highest in children aged 5-9 years and adults ≥85 years. G2P[4] was the dominant genotype in the population ≥5 years of age. Genotype distribution fluctuated annually and genotypic diversity varied among different age groups. Geographical differences in genotype distribution were observed based on the rotavirus vaccine administered to infants <1 year of age.<br />Conclusions: This study revealed a substantial burden of rotavirus disease in the population ≥5 years of age, particularly in children 5-9 years and the elderly. This study highlights the continued need for rotavirus surveillance across the population, despite the implementation of efficacious vaccines.<br /> (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.)
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 225
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 32692812
- Full Text :
- https://doi.org/10.1093/infdis/jiaa430