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A Genomic Test for Colorectal Cancer Risk: Is This Acceptable and Feasible in Primary Care?
- Source :
-
Public health genomics [Public Health Genomics] 2020; Vol. 23 (3-4), pp. 110-121. Date of Electronic Publication: 2020 Jul 20. - Publication Year :
- 2020
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Abstract
- Introduction: Genomic tests can predict risk and tailor screening recommendations for colorectal cancer (CRC). Primary care could be suitable for their widespread implementation.<br />Objective: We aimed to assess the feasibility and acceptability of administering a CRC genomic test in primary care.<br />Methods: Participants aged 45-74 years recruited from 4 Australian general practices were offered a genomic CRC risk test. Participants received brief verbal information about the test comprising 45 CRC-associated single-nucleotide polymorphisms, before choosing whether to undertake the test. Personalized risks were given to testers. Uptake and knowledge of the genomic test, cancer-specific anxiety (Cancer Worry Scale), psychosocial impact (Multidimensional Impact of Cancer Risk Assessment [MICRA] score), and impact on CRC screening behaviour within 6 months were measured.<br />Results: In 150 participants, test uptake was high (126, 84%), with 125 (83%) having good knowledge of the genomic test. Moderate risk participants were impacted more by the test (MICRA mean: 15.9) than average risk participants (mean: 9.5, difference in means: 6.4, 95% confidence interval (CI): 1.5, 11.2, p = 0.01), but all scores were low. Average risk participants' cancer-specific anxiety decreased (mean differences from baseline: 1 month -0.5, 95% CI: -1.0, -0.1, p = 0.03; 6 months -0.6, 95% CI: -1.0, -0.2, p = 0.01). We found limited evidence for genomic testers being more likely to complete the risk-appropriate CRC screening than non-testers (41 vs. 17%, odds ratio = 3.4, 95% CI: 0.6, 34.8, p = 0.19), but some mediators of screening behaviour were altered in genomic testers.<br />Conclusions: Genomic testing for CRC risk in primary care is acceptable and likely feasible. Further development of the risk assessment intervention could strengthen the impact on screening behaviour.<br /> (© 2020 S. Karger AG, Basel.)
- Subjects :
- Aged
Attitude to Health
Australia epidemiology
Female
Humans
Male
Middle Aged
Psycho-Oncology
Social Perception
Colorectal Neoplasms diagnosis
Colorectal Neoplasms genetics
Colorectal Neoplasms psychology
Early Detection of Cancer methods
Early Detection of Cancer psychology
Genetic Testing methods
Primary Health Care methods
Primary Health Care organization & administration
Risk Assessment methods
Subjects
Details
- Language :
- English
- ISSN :
- 1662-8063
- Volume :
- 23
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Public health genomics
- Publication Type :
- Academic Journal
- Accession number :
- 32688362
- Full Text :
- https://doi.org/10.1159/000508963