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Recent insights into the biology of Barrett's esophagus.
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Dec; Vol. 1481 (1), pp. 198-209. Date of Electronic Publication: 2020 Jul 17. - Publication Year :
- 2020
-
Abstract
- Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), an aggressive cancer with a poor prognosis. Our understanding of the pathogenesis and Barrett's metaplasia is incomplete, and this has limited the development of new therapeutic targets and agents, risk stratification ability, and management strategies. This review outlines current insights into the biology of BE and addresses controversies surrounding cell of origin, cellular reprogramming theories, updates on esophageal epithelial barrier function, and the significance of goblet cell metaplasia and its association with malignant change. Further research into the basic biology of BE is vital as it will underpin novel therapies and improve our ability to predict malignant progression and help identify the minority of patients who will develop EAC.<br /> (© 2020 New York Academy of Sciences.)
- Subjects :
- Humans
Metaplasia
Adenocarcinoma metabolism
Adenocarcinoma pathology
Adenocarcinoma physiopathology
Barrett Esophagus metabolism
Barrett Esophagus pathology
Barrett Esophagus physiopathology
Esophageal Mucosa metabolism
Esophageal Mucosa pathology
Esophageal Mucosa physiopathology
Esophageal Neoplasms metabolism
Esophageal Neoplasms pathology
Esophageal Neoplasms physiopathology
Goblet Cells metabolism
Goblet Cells pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1749-6632
- Volume :
- 1481
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32681541
- Full Text :
- https://doi.org/10.1111/nyas.14432