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Human IDH mutant 1p/19q co-deleted gliomas have low tumor acidity as evidenced by molecular MRI and PET: a retrospective study.
- Source :
-
Scientific reports [Sci Rep] 2020 Jul 17; Vol. 10 (1), pp. 11922. Date of Electronic Publication: 2020 Jul 17. - Publication Year :
- 2020
-
Abstract
- Co-deletion of 1p/19q is a hallmark of oligodendroglioma and predicts better survival. However, little is understood about its metabolic characteristics. In this study, we aimed to explore the extracellular acidity of WHO grade II and III gliomas associated with 1p/19q co-deletion. We included 76 glioma patients who received amine chemical exchange saturation transfer (CEST) imaging at 3 T. Magnetic transfer ratio asymmetry (MTR <subscript>asym</subscript> ) at 3.0 ppm was used as the pH-sensitive CEST biomarker, with higher MTR <subscript>asym</subscript> indicating lower pH. To control for the confounder factors, T <subscript>2</subscript> relaxometry and L-6- <superscript>18</superscript> F-fluoro-3,4-dihydroxyphenylalnine ( <superscript>18</superscript> F-FDOPA) PET data were collected in a subset of patients. We found a significantly lower MTR <subscript>asym</subscript> in 1p/19q co-deleted gliomas (co-deleted, 1.17% ± 0.32%; non-co-deleted, 1.72% ± 0.41%, P = 1.13 × 10 <superscript>-7</superscript> ), while FDOPA (P = 0.92) and T <subscript>2</subscript> (P = 0.61) were not significantly affected. Receiver operating characteristic analysis confirmed that MTR <subscript>asym</subscript> could discriminate co-deletion status with an area under the curve of 0.85. In analysis of covariance, 1p/19q co-deletion status was the only significant contributor to the variability in MTR <subscript>asym</subscript> when controlling for age and FDOPA (P = 2.91 × 10 <superscript>-3</superscript> ) or T <subscript>2</subscript> (P = 8.03 × 10 <superscript>-6</superscript> ). In conclusion, 1p/19q co-deleted gliomas were less acidic, which may be related to better prognosis. Amine CEST-MRI may serve as a non-invasive biomarker for identifying 1p/19q co-deletion status.
- Subjects :
- Adult
Aged
Aged, 80 and over
Amines analysis
Brain Neoplasms diagnostic imaging
Contrast Media chemistry
Dihydroxyphenylalanine analogs & derivatives
Dihydroxyphenylalanine chemistry
Female
Glioma diagnostic imaging
Humans
Hydrogen-Ion Concentration
Magnetic Phenomena
Male
Middle Aged
Phantoms, Imaging
Young Adult
Brain Neoplasms genetics
Chromosome Deletion
Chromosomes, Human, Pair 1 genetics
Glioma genetics
Isocitrate Dehydrogenase genetics
Magnetic Resonance Imaging
Mutation genetics
Positron-Emission Tomography
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32681084
- Full Text :
- https://doi.org/10.1038/s41598-020-68733-5