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Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis.
- Source :
-
Mucosal immunology [Mucosal Immunol] 2021 Mar; Vol. 14 (2), pp. 491-499. Date of Electronic Publication: 2020 Jul 16. - Publication Year :
- 2021
-
Abstract
- Recent data from mice and non-human primate models of tuberculosis suggested that CD153, a TNF super family member, plays an important role in Mycobacterium tuberculosis (Mtb) control. However, this molecule has not been comprehensively evaluated in humans. Here, we show that the proportion of Mtb-specific CD4 T cells expressing CD153 was significantly reduced in active TB patients compared to latently infected persons. Importantly, the CD153+ Mtb-specific CD4 response inversely correlated with lung bacterial load, inferred by Xpert cycle threshold, irrespective of HIV status. Antitubercular treatment partially restored CD153 expression on Mtb-specific CD4 T cells. This is the first report of a subset of Mtb-specific CD4 T cells showing strong negative correlation with bacterial burden. Building on substantial evidence from animal models implicating CD153 as a mediator of host protection, our findings suggest it may play a similar role in humans and its measurement may be useful to evaluate TB vaccine efficacy.
- Subjects :
- Adult
Animals
Bacterial Load
CD30 Ligand genetics
Disease Models, Animal
Female
Humans
Lung microbiology
Male
T-Cell Antigen Receptor Specificity
Young Adult
CD30 Ligand metabolism
CD4-Positive T-Lymphocytes immunology
Lung immunology
Mycobacterium tuberculosis physiology
Tuberculosis Vaccines immunology
Tuberculosis, Pulmonary immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1935-3456
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Mucosal immunology
- Publication Type :
- Academic Journal
- Accession number :
- 32678272
- Full Text :
- https://doi.org/10.1038/s41385-020-0322-6