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Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin.
- Source :
-
Journal of molecular neuroscience : MN [J Mol Neurosci] 2021 Feb; Vol. 71 (2), pp. 347-357. Date of Electronic Publication: 2020 Jul 16. - Publication Year :
- 2021
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Abstract
- Musculoskeletal pain is a widespread complex regional pain syndrome associated with altered emotional and cognitive functioning along with heightened physical disability that has become a global health concern. Effective management of this disorder and associated disabilities includes accurate diagnosis of its biomarkers and instituting mechanism-based therapeutic interventions. Herein, we explored the role of heraclin, a plant-derived molecule, in musculoskeletal pain and its underlying mechanistic approaches in an experimental mouse model. Reserpine (0.5 mg/kg) for 3 consecutive days evoked hyperalgesia, motor incoordination, lack of exploratory behavior, anxiety, and cognition lapse in mice. Reserpine-challenged mice displayed higher serum cytokine level, altered brain neurotransmitter content, elevated brain and muscle oxidative stress, and upregulated brain nerve growth factor receptor expression. Treatment with heraclin (10 mg/kg for 5 consecutive days) exerted analgesic effect and improved motor coordination and memory deficits in mice. Heraclin arrested serum cytokine rise, normalized brain neurotransmitter content, reduced tissue oxidative stress, and downregulated the nerve growth factor receptor expression. Therefore, it may be suggested that heraclin exerts beneficial effects against reserpine-induced musculoskeletal pain disorder possibly through the attenuation of NGFR-mediated pain and inflammatory signaling. Graphical Abstract.
- Subjects :
- Animals
Anxiety chemically induced
Brain Chemistry drug effects
Cognition Disorders chemically induced
Cytokines blood
Drug Evaluation, Preclinical
Exploratory Behavior drug effects
Furocoumarins pharmacology
Gabapentin therapeutic use
Hyperalgesia chemically induced
Hyperalgesia drug therapy
Hyperalgesia physiopathology
Mice
Morris Water Maze Test
Motor Activity drug effects
Musculoskeletal Pain chemically induced
Musculoskeletal Pain physiopathology
Neurotransmitter Agents analysis
Random Allocation
Reserpine toxicity
Thiobarbituric Acid Reactive Substances analysis
Analgesics therapeutic use
Drugs, Chinese Herbal therapeutic use
Furocoumarins therapeutic use
Musculoskeletal Pain drug therapy
Nerve Growth Factor physiology
Oxidative Stress
Phytotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 1559-1166
- Volume :
- 71
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of molecular neuroscience : MN
- Publication Type :
- Academic Journal
- Accession number :
- 32676972
- Full Text :
- https://doi.org/10.1007/s12031-020-01656-y