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Geographical Profiles of COVID-19 Outbreak in Tokyo: An Analysis of the Primary Care Clinic-Based Point-of-Care Antibody Testing.
- Source :
-
Journal of primary care & community health [J Prim Care Community Health] 2020 Jan-Dec; Vol. 11, pp. 2150132720942695. - Publication Year :
- 2020
-
Abstract
- Introduction: The primary care clinic plays a major role in triage for coronavirus disease 2019 (COVID-19), where seroprevalence in the setting of primary care clinic remains less clear. As a point-of-care immunodiagnostic test for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the serosurvey represents an alternative to the polymerase chain reaction (PCR) test to measure the magnitude of COVID-19 outbreak in the communities lacking sufficient diagnostic capability for PCR testing. Methods: We assessed seropositivity for the SARS-CoV-2 IgG between April 21 and May 20, 2020, at 2 primary care clinics in Tokyo, Japan. Results: The overall positive percentage of SARS-CoV-2 IgG was 3.83% (95% confidence interval [CI]: 2.76-5.16) for the entire cohort (n = 1071). The 23 special wards of central Tokyo exhibited a significantly higher prevalence compared with the other areas of Tokyo after classification by residence ( P = .02, 4.68% [3.08-6.79] vs 1.83 [0.68-3.95] in central and suburban Tokyo, respectively). In central Tokyo, the southern area showed the highest seroprevalence compared with the other areas (7.92% [3.48-15.01]), corresponding to the cumulative number of confirmed COVID-19 patients by PCR test reported by the Tokyo Metropolitan Government. Conclusion: The seroprevalence surveyed in this study was too low for herd immunity, suggesting the need for robust disease control and prevention. A regional-level approach, rather than state- or prefectural-level, could be of importance in ascertaining detailed profiles of the COVID-19 outbreak.
- Subjects :
- Adolescent
Adult
Antibodies, Viral blood
Betacoronavirus immunology
COVID-19
COVID-19 Testing
Clinical Laboratory Techniques
Female
Humans
Immunoglobulin G blood
Male
Middle Aged
Pandemics
Point-of-Care Systems
SARS-CoV-2
Seroepidemiologic Studies
Tokyo epidemiology
Young Adult
Coronavirus Infections diagnosis
Coronavirus Infections epidemiology
Disease Outbreaks
Pneumonia, Viral diagnosis
Pneumonia, Viral epidemiology
Primary Health Care
Residence Characteristics statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 2150-1327
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of primary care & community health
- Publication Type :
- Academic Journal
- Accession number :
- 32674696
- Full Text :
- https://doi.org/10.1177/2150132720942695